2021 American Athletic Conference Leaders Passing Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 2 | 81 | 50 | 61.7 | 652 | 8.0 | 2 | 2 | 132.55 | 40.5 | 326.0 |
| 2 | Houston | 2 | 79 | 53 | 67.1 | 457 | 5.8 | 4 | 6 | 117.20 | 39.5 | 228.5 |
| 3 | Cincinnati | 2 | 68 | 37 | 54.4 | 354 | 5.2 | 1 | 1 | 100.05 | 34.0 | 177.0 |
| 4 | Tulane | 2 | 63 | 37 | 58.7 | 462 | 7.3 | 5 | 0 | 146.52 | 31.5 | 231.0 |
| 4 | South Florida | 2 | 63 | 31 | 49.2 | 355 | 5.6 | 0 | 4 | 83.84 | 31.5 | 177.5 |
| 6 | SMU | 1 | 28 | 17 | 60.7 | 245 | 8.8 | 4 | 3 | 159.92 | 28.0 | 245.0 |
| 6 | Memphis | 1 | 28 | 16 | 57.1 | 159 | 5.7 | 2 | 1 | 121.27 | 28.0 | 159.0 |
| 8 | UCF | 2 | 55 | 38 | 69.1 | 352 | 6.4 | 5 | 1 | 149.21 | 27.5 | 176.0 |
| 9 | Temple | 2 | 51 | 25 | 49.0 | 309 | 6.1 | 0 | 2 | 92.08 | 25.5 | 154.5 |
| 10 | East Carolina | 1 | 25 | 12 | 48.0 | 152 | 6.1 | 1 | 2 | 96.27 | 25.0 | 152.0 |