2021 American Athletic Conference Leaders Passing Offense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 10 | 405 | 274 | 67.7 | 3283 | 8.1 | 35 | 11 | 158.83 | 40.5 | 328.3 |
| 2 | Memphis | 11 | 399 | 246 | 61.7 | 3369 | 8.4 | 25 | 9 | 148.75 | 36.3 | 306.3 |
| 3 | East Carolina | 10 | 348 | 218 | 62.6 | 2747 | 7.9 | 18 | 10 | 140.27 | 34.8 | 274.7 |
| 4 | Houston | 13 | 432 | 290 | 67.1 | 3552 | 8.2 | 30 | 11 | 154.02 | 33.2 | 273.2 |
| 5 | Tulane | 8 | 264 | 147 | 55.7 | 1892 | 7.2 | 16 | 11 | 127.55 | 33.0 | 236.5 |
| 6 | Temple | 10 | 307 | 184 | 59.9 | 1857 | 6.0 | 10 | 5 | 118.24 | 30.7 | 185.7 |
| 7 | UCF | 12 | 363 | 236 | 65.0 | 2539 | 7.0 | 28 | 7 | 145.35 | 30.3 | 211.6 |
| 8 | Tulsa | 9 | 264 | 156 | 59.1 | 2174 | 8.2 | 14 | 11 | 137.43 | 29.3 | 241.6 |
| 9 | Cincinnati | 11 | 319 | 210 | 65.8 | 2746 | 8.6 | 28 | 9 | 161.46 | 29.0 | 249.6 |
| 10 | South Florida | 8 | 221 | 122 | 55.2 | 1422 | 6.4 | 3 | 5 | 109.21 | 27.6 | 177.8 |
| 11 | Navy | 9 | 69 | 32 | 46.4 | 449 | 6.5 | 6 | 2 | 123.94 | 7.7 | 49.9 |