2021 American Athletic Conference Leaders Tackles For Loss - Games in October Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | University of Houston | 4 | 36.0 | 161 | 9.00 |
| 2 | University of Cincinnati | 5 | 39.0 | 149 | 7.80 |
| 3 | East Carolina University | 4 | 28.0 | 124 | 7.00 |
| 4 | Southern Methodist University | 4 | 27.0 | 91 | 6.75 |
| 5 | University of Central Florida | 5 | 27.0 | 118 | 5.40 |
| 6 | U.S. Naval Academy | 5 | 25.0 | 77 | 5.00 |
| 6 | Tulane University | 4 | 20.0 | 85 | 5.00 |
| 8 | Temple University | 4 | 19.0 | 63 | 4.75 |
| 8 | The University of Tulsa | 4 | 19.0 | 53 | 4.75 |
| 10 | University of Memphis | 4 | 18.0 | 69 | 4.50 |
| 10 | University of South Florida | 4 | 18.0 | 62 | 4.50 |