2021 American Athletic Conference Leaders Tackles For Loss - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | University of Cincinnati | 8 | 55.0 | 222 | 6.88 |
| 2 | East Carolina University | 6 | 41.0 | 172 | 6.83 |
| 3 | Tulane University | 9 | 61.0 | 237 | 6.78 |
| 4 | University of Central Florida | 4 | 27.0 | 96 | 6.75 |
| 5 | University of Houston | 5 | 32.0 | 130 | 6.40 |
| 5 | Temple University | 5 | 32.0 | 98 | 6.40 |
| 7 | University of Memphis | 7 | 44.0 | 179 | 6.29 |
| 8 | Southern Methodist University | 4 | 22.0 | 80 | 5.50 |
| 9 | U.S. Naval Academy | 10 | 53.0 | 165 | 5.30 |
| 10 | The University of Tulsa | 5 | 25.0 | 87 | 5.00 |
| 11 | University of South Florida | 8 | 34.0 | 99 | 4.25 |