2021 American Athletic Conference Leaders Sacks Allowed - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | SMU | 10 | 16.0 | 112 | 1.60 |
| 1 | Cincinnati | 11 | 16.0 | 120 | 1.46 |
| 3 | Tulsa | 10 | 17.0 | 66 | 1.70 |
| 4 | Temple | 9 | 20.0 | 118 | 2.22 |
| 4 | UCF | 10 | 20.0 | 124 | 2.00 |
| 4 | South Florida | 9 | 20.0 | 155 | 2.22 |
| 7 | Tulane | 9 | 26.0 | 171 | 2.89 |
| 8 | Memphis | 10 | 28.0 | 157 | 2.80 |
| 9 | East Carolina | 10 | 29.0 | 166 | 2.90 |
| 9 | Houston | 11 | 29.0 | 212 | 2.64 |
| 11 | Navy | 12 | 30.0 | 165 | 2.50 |