2021 American Athletic Conference Leaders Sacks Allowed - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | SMU | 1 | 0.0 | 0 | 0.00 |
| 2 | Memphis | 1 | 1.0 | 3 | 1.00 |
| 3 | South Florida | 2 | 3.0 | 9 | 1.50 |
| 4 | Tulane | 2 | 6.0 | 28 | 3.00 |
| 5 | UCF | 2 | 4.0 | 33 | 2.00 |
| 5 | Temple | 2 | 7.0 | 33 | 3.50 |
| 7 | Houston | 2 | 5.0 | 39 | 2.50 |
| 8 | East Carolina | 1 | 5.0 | 41 | 5.00 |
| 9 | Tulsa | 2 | 4.0 | 42 | 2.00 |
| 10 | Cincinnati | 2 | 8.0 | 44 | 4.00 |