2021 American Athletic Conference Leaders Rushing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 4 | 110 | 397 | 3.61 | 3 | 27.50 | 99.25 |
| 2 | Tulane | 4 | 152 | 421 | 2.77 | 4 | 38.00 | 105.25 |
| 3 | Tulsa | 4 | 138 | 484 | 3.51 | 5 | 34.50 | 121.00 |
| 3 | Cincinnati | 4 | 164 | 585 | 3.57 | 5 | 41.00 | 146.25 |
| 3 | East Carolina | 4 | 134 | 695 | 5.19 | 5 | 33.50 | 173.75 |
| 6 | Navy | 3 | 94 | 392 | 4.17 | 6 | 31.33 | 130.67 |
| 7 | UCF | 4 | 151 | 598 | 3.96 | 8 | 37.75 | 149.50 |
| 8 | SMU | 4 | 142 | 544 | 3.83 | 9 | 35.50 | 136.00 |
| 9 | Memphis | 4 | 166 | 748 | 4.51 | 10 | 41.50 | 187.00 |
| 10 | South Florida | 4 | 137 | 826 | 6.03 | 12 | 34.25 | 206.50 |
| 10 | Temple | 4 | 188 | 897 | 4.77 | 12 | 47.00 | 224.25 |