2021 American Athletic Conference Leaders Rushing Defense - Games Won Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulane | 2 | 73 | 167 | 2.29 | 2 | 36.50 | 83.50 |
| 1 | South Florida | 2 | 43 | 180 | 4.19 | 2 | 21.50 | 90.00 |
| 3 | Temple | 3 | 129 | 451 | 3.50 | 3 | 43.00 | 150.33 |
| 4 | Navy | 4 | 120 | 485 | 4.04 | 5 | 30.00 | 121.25 |
| 5 | Houston | 12 | 389 | 1160 | 2.98 | 8 | 32.42 | 96.67 |
| 5 | UCF | 9 | 288 | 954 | 3.31 | 8 | 32.00 | 106.00 |
| 5 | Tulsa | 7 | 222 | 748 | 3.37 | 8 | 31.71 | 106.86 |
| 5 | Memphis | 6 | 214 | 811 | 3.79 | 8 | 35.67 | 135.17 |
| 9 | SMU | 8 | 286 | 1154 | 4.03 | 9 | 35.75 | 144.25 |
| 10 | East Carolina | 7 | 234 | 1220 | 5.21 | 13 | 33.43 | 174.29 |
| 11 | Cincinnati | 13 | 536 | 1787 | 3.33 | 14 | 41.23 | 137.46 |