2021 American Athletic Conference Leaders Rushing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 9 | 286 | 984 | 3.44 | 10 | 31.78 | 109.33 |
| 1 | Cincinnati | 9 | 389 | 1289 | 3.31 | 10 | 43.22 | 143.22 |
| 3 | Navy | 8 | 237 | 1021 | 4.31 | 12 | 29.63 | 127.63 |
| 3 | East Carolina | 8 | 262 | 1270 | 4.85 | 12 | 32.75 | 158.75 |
| 5 | SMU | 8 | 309 | 1105 | 3.58 | 13 | 38.63 | 138.13 |
| 6 | Tulsa | 8 | 304 | 1194 | 3.93 | 14 | 38.00 | 149.25 |
| 7 | Tulane | 8 | 307 | 1176 | 3.83 | 15 | 38.38 | 147.00 |
| 8 | UCF | 8 | 337 | 1493 | 4.43 | 16 | 42.13 | 186.63 |
| 8 | Memphis | 8 | 351 | 1553 | 4.42 | 16 | 43.88 | 194.13 |
| 10 | South Florida | 8 | 291 | 1556 | 5.35 | 18 | 36.38 | 194.50 |
| 11 | Temple | 8 | 375 | 1953 | 5.21 | 22 | 46.88 | 244.13 |