2021 American Athletic Conference Leaders Passing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 9 | 242 | 140 | 57.9 | 1449 | 6.0 | 7 | 10 | 109.44 | 26.9 | 161.0 |
| 2 | Navy | 8 | 217 | 149 | 68.7 | 1818 | 8.4 | 13 | 5 | 154.20 | 27.1 | 227.3 |
| 3 | Temple | 8 | 218 | 140 | 64.2 | 1704 | 7.8 | 21 | 3 | 158.92 | 27.3 | 213.0 |
| 4 | East Carolina | 8 | 226 | 130 | 57.5 | 1475 | 6.5 | 11 | 10 | 119.56 | 28.3 | 184.4 |
| 5 | Memphis | 8 | 239 | 147 | 61.5 | 1617 | 6.8 | 12 | 8 | 128.22 | 29.9 | 202.1 |
| 6 | SMU | 8 | 246 | 150 | 61.0 | 2113 | 8.6 | 18 | 4 | 154.03 | 30.8 | 264.1 |
| 7 | Houston | 9 | 286 | 157 | 54.9 | 1967 | 6.9 | 14 | 11 | 121.14 | 31.8 | 218.6 |
| 7 | Tulsa | 8 | 254 | 140 | 55.1 | 1791 | 7.1 | 9 | 7 | 120.53 | 31.8 | 223.9 |
| 9 | South Florida | 8 | 255 | 171 | 67.1 | 2072 | 8.1 | 17 | 7 | 151.82 | 31.9 | 259.0 |
| 10 | UCF | 8 | 259 | 159 | 61.4 | 1558 | 6.0 | 6 | 5 | 115.71 | 32.4 | 194.8 |
| 11 | Tulane | 8 | 275 | 178 | 64.7 | 2182 | 7.9 | 18 | 5 | 149.34 | 34.4 | 272.8 |