2021 American Athletic Conference Leaders Passing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 4 | 92 | 56 | 60.9 | 933 | 10.1 | 8 | 1 | 172.58 | 23.0 | 233.3 |
| 2 | Memphis | 4 | 98 | 64 | 65.3 | 627 | 6.4 | 8 | 1 | 143.95 | 24.5 | 156.8 |
| 3 | Navy | 5 | 132 | 85 | 64.4 | 1058 | 8.0 | 9 | 5 | 146.64 | 26.4 | 211.6 |
| 4 | Cincinnati | 5 | 140 | 77 | 55.0 | 757 | 5.4 | 2 | 8 | 93.71 | 28.0 | 151.4 |
| 5 | Temple | 4 | 114 | 77 | 67.5 | 902 | 7.9 | 12 | 1 | 166.99 | 28.5 | 225.5 |
| 6 | UCF | 5 | 143 | 85 | 59.4 | 799 | 5.6 | 3 | 4 | 107.70 | 28.6 | 159.8 |
| 7 | Tulsa | 4 | 116 | 64 | 55.2 | 879 | 7.6 | 4 | 3 | 125.04 | 29.0 | 219.8 |
| 8 | East Carolina | 4 | 132 | 80 | 60.6 | 835 | 6.3 | 4 | 7 | 113.14 | 33.0 | 208.8 |
| 9 | South Florida | 4 | 138 | 85 | 61.6 | 960 | 7.0 | 8 | 5 | 131.91 | 34.5 | 240.0 |
| 10 | Tulane | 4 | 141 | 93 | 66.0 | 1255 | 8.9 | 12 | 1 | 167.40 | 35.3 | 313.8 |
| 11 | Houston | 4 | 144 | 87 | 60.4 | 1055 | 7.3 | 8 | 4 | 134.73 | 36.0 | 263.8 |