2021 American Athletic Conference Leaders Passing - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Seth Henigan | Memphis | FR | QB | 10 | 348 | 214 | 61.5 | 3114 | 8.9 | 24 | 6 | 155.96 | 34.8 | 311.4 |
| 2 | Desmond Ridder | Cincinnati | SR | QB | 11 | 306 | 204 | 66.7 | 2703 | 8.8 | 25 | 8 | 162.60 | 27.8 | 245.7 |
| 3 | Clayton Tune | Houston | JR | QB | 13 | 394 | 270 | 68.5 | 3296 | 8.4 | 28 | 9 | 157.68 | 30.3 | 253.5 |
| 4 | Tanner Mordecai | SMU | JR | QB | 10 | 391 | 269 | 68.8 | 3257 | 8.3 | 35 | 11 | 162.68 | 39.1 | 325.7 |
| 5 | Davis Brin | Tulsa | JR | QB | 9 | 264 | 156 | 59.1 | 2174 | 8.2 | 14 | 11 | 137.43 | 29.3 | 241.6 |
| 6 | Holton Ahlers | ECU | JR | QB | 10 | 339 | 214 | 63.1 | 2624 | 7.7 | 15 | 9 | 137.44 | 33.9 | 262.4 |
| 7 | Michael Pratt | Tulane | FR | QB | 8 | 236 | 132 | 55.9 | 1705 | 7.2 | 14 | 8 | 129.42 | 29.5 | 213.1 |
| 8 | Timmy McClain | S Florida | FR | QB | 7 | 149 | 83 | 55.7 | 1042 | 7.0 | 2 | 1 | 117.54 | 21.3 | 148.9 |
| 9 | Mikey Keene | UCF | FR | QB | 10 | 245 | 157 | 64.1 | 1589 | 6.5 | 16 | 4 | 136.84 | 24.5 | 158.9 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.