2021 American Athletic Conference Leaders Passing - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Clayton Tune | Houston | JR | QB | 1 | 26 | 17 | 65.4 | 250 | 9.6 | 2 | 1 | 163.85 | 26.0 | 250.0 |
| 2 | Michael Pratt | Tulane | FR | QB | 4 | 92 | 57 | 62.0 | 676 | 7.3 | 7 | 0 | 148.79 | 23.0 | 169.0 |
| 3 | Tanner Mordecai | SMU | JR | QB | 2 | 63 | 39 | 61.9 | 371 | 5.9 | 4 | 1 | 129.16 | 31.5 | 185.5 |
| 4 | Davis Brin | Tulsa | JR | QB | 4 | 147 | 88 | 59.9 | 1070 | 7.3 | 4 | 5 | 123.18 | 36.8 | 267.5 |
| 5 | Mikey Keene | UCF | FR | QB | 1 | 27 | 16 | 59.3 | 141 | 5.2 | 1 | 2 | 100.53 | 27.0 | 141.0 |
| 6 | Desmond Ridder | Cincinnati | SR | QB | 3 | 81 | 47 | 58.0 | 631 | 7.8 | 5 | 0 | 143.84 | 27.0 | 210.3 |
| 7 | Holton Ahlers | ECU | JR | QB | 2 | 75 | 42 | 56.0 | 506 | 6.7 | 3 | 1 | 123.20 | 37.5 | 253.0 |
| 8 | Timmy McClain | S Florida | FR | QB | 4 | 113 | 62 | 54.9 | 846 | 7.5 | 3 | 6 | 115.90 | 28.3 | 211.5 |
| 9 | Seth Henigan | Memphis | FR | QB | 1 | 45 | 21 | 46.7 | 208 | 4.6 | 1 | 2 | 83.93 | 45.0 | 208.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.