2021 Atlantic Coast Conference Leaders Fumbles Lost - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Fumbles | Fumbles Lost | Fumble Lost % | |
|---|---|---|---|---|---|
| 1 | Georgia Tech | 9 | 7 | 2 | 28.57 |
| 2 | Virginia | 9 | 17 | 5 | 29.41 |
| 3 | Pittsburgh | 11 | 8 | 3 | 37.50 |
| 4 | Boston College | 9 | 13 | 5 | 38.46 |
| 5 | North Carolina | 10 | 9 | 4 | 44.44 |
| 6 | Clemson | 11 | 13 | 6 | 46.15 |
| 7 | Syracuse | 9 | 12 | 6 | 50.00 |
| 7 | Virginia Tech | 10 | 12 | 6 | 50.00 |
| 9 | Florida State | 9 | 15 | 8 | 53.33 |
| 10 | Miami (Florida) | 10 | 13 | 7 | 53.85 |
| 11 | Louisville | 10 | 11 | 6 | 54.55 |
| 12 | North Carolina State | 9 | 7 | 4 | 57.14 |
| 12 | Wake Forest | 11 | 7 | 4 | 57.14 |
| 14 | Duke | 10 | 15 | 10 | 66.67 |