2021 Atlantic Coast Conference Leaders Interceptions - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 13 | 15 | 230 | 3 | 1.15 |
| 2 | Louisville | 12 | 8 | 159 | 1 | 0.67 |
| 3 | Florida State | 11 | 14 | 150 | 1 | 1.27 |
| 4 | Wake Forest | 13 | 14 | 147 | 1 | 1.08 |
| 5 | Virginia | 11 | 8 | 126 | 0 | 0.73 |
| 6 | Miami (Florida) | 11 | 7 | 113 | 1 | 0.64 |
| 7 | Duke | 11 | 8 | 101 | 0 | 0.73 |
| 8 | Virginia Tech | 12 | 10 | 97 | 1 | 0.83 |
| 9 | North Carolina | 12 | 10 | 62 | 0 | 0.83 |
| 10 | Clemson | 12 | 11 | 32 | 1 | 0.92 |
| 10 | Syracuse | 11 | 4 | 32 | 0 | 0.36 |
| 12 | North Carolina State | 11 | 14 | 28 | 1 | 1.27 |
| 13 | Georgia Tech | 11 | 1 | 6 | 0 | 0.09 |
| 14 | Boston College | 11 | 8 | 5 | 0 | 0.73 |