2021 Atlantic Coast Conference Leaders Interceptions - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 9 | 13 | 205 | 3 | 1.44 |
| 2 | Virginia | 8 | 6 | 126 | 0 | 0.75 |
| 3 | Miami (Florida) | 8 | 6 | 113 | 1 | 0.75 |
| 4 | Louisville | 8 | 7 | 93 | 0 | 0.88 |
| 5 | Florida State | 8 | 8 | 47 | 0 | 1.00 |
| 6 | Duke | 8 | 3 | 46 | 0 | 0.38 |
| 7 | North Carolina | 9 | 9 | 45 | 0 | 1.00 |
| 8 | Virginia Tech | 8 | 6 | 16 | 0 | 0.75 |
| 9 | Wake Forest | 10 | 9 | 15 | 0 | 0.90 |
| 10 | Boston College | 8 | 4 | 12 | 0 | 0.50 |
| 11 | Clemson | 8 | 5 | 9 | 0 | 0.63 |
| 11 | Syracuse | 8 | 3 | 9 | 0 | 0.38 |
| 13 | North Carolina State | 8 | 9 | 6 | 1 | 1.13 |
| 13 | Georgia Tech | 8 | 1 | 6 | 0 | 0.13 |