2021 Atlantic Coast Conference Leaders First Downs - Games in December/January Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 2 | 18 | 26 | 8 | 52 | 26.0 |
| 2 | Pittsburgh | 2 | 16 | 17 | 3 | 36 | 18.0 |
| 3 | Louisville | 1 | 13 | 9 | 1 | 23 | 23.0 |
| 4 | Clemson | 1 | 8 | 10 | 2 | 20 | 20.0 |
| 5 | North Carolina | 1 | 5 | 9 | 0 | 14 | 14.0 |
| 6 | Virginia Tech | 1 | 5 | 7 | 1 | 13 | 13.0 |