2021 Atlantic Coast Conference Leaders First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 5 | 51 | 73 | 9 | 133 | 26.6 |
| 2 | Louisville | 5 | 43 | 57 | 7 | 107 | 21.4 |
| 3 | Clemson | 5 | 44 | 49 | 11 | 104 | 20.8 |
| 4 | Miami (Florida) | 4 | 41 | 49 | 13 | 103 | 25.8 |
| 5 | Duke | 4 | 46 | 50 | 4 | 100 | 25.0 |
| 5 | North Carolina | 4 | 44 | 51 | 5 | 100 | 25.0 |
| 7 | Virginia | 4 | 34 | 57 | 7 | 98 | 24.5 |
| 7 | Virginia Tech | 5 | 41 | 48 | 9 | 98 | 19.6 |
| 9 | Wake Forest | 4 | 30 | 50 | 12 | 92 | 23.0 |
| 10 | North Carolina State | 4 | 29 | 53 | 9 | 91 | 22.8 |
| 11 | Florida State | 4 | 44 | 32 | 11 | 87 | 21.8 |
| 12 | Boston College | 4 | 49 | 32 | 5 | 86 | 21.5 |
| 13 | Syracuse | 4 | 44 | 30 | 7 | 81 | 20.3 |
| 14 | Georgia Tech | 4 | 36 | 27 | 2 | 65 | 16.3 |