2021 Atlantic Coast Conference Leaders Rushing Offense - Games in December/January Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 2 | 76 | 230 | 3.03 | 2 | 38.00 | 115.00 |
| 2 | Pittsburgh | 2 | 70 | 216 | 3.09 | 4 | 35.00 | 108.00 |
| 3 | Virginia Tech | 1 | 48 | 122 | 2.54 | 1 | 48.00 | 122.00 |
| 4 | Louisville | 1 | 41 | 232 | 5.66 | 2 | 41.00 | 232.00 |
| 5 | Clemson | 1 | 40 | 128 | 3.20 | 1 | 40.00 | 128.00 |
| 6 | North Carolina | 1 | 29 | 128 | 4.41 | 1 | 29.00 | 128.00 |