2021 Atlantic Coast Conference Leaders Rushing Offense - Games in October Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Syracuse | 5 | 220 | 1365 | 6.20 | 13 | 44.00 | 273.00 |
| 2 | Duke | 4 | 174 | 597 | 3.43 | 2 | 43.50 | 149.25 |
| 3 | Louisville | 4 | 165 | 987 | 5.98 | 8 | 41.25 | 246.75 |
| 4 | Virginia Tech | 4 | 162 | 714 | 4.41 | 5 | 40.50 | 178.50 |
| 5 | North Carolina | 4 | 161 | 815 | 5.06 | 9 | 40.25 | 203.75 |
| 6 | Florida State | 4 | 157 | 915 | 5.83 | 9 | 39.25 | 228.75 |
| 7 | Pittsburgh | 4 | 151 | 619 | 4.10 | 5 | 37.75 | 154.75 |
| 8 | Clemson | 4 | 150 | 699 | 4.66 | 6 | 37.50 | 174.75 |
| 9 | Wake Forest | 4 | 146 | 718 | 4.92 | 11 | 36.50 | 179.50 |
| 10 | Boston College | 4 | 140 | 327 | 2.34 | 2 | 35.00 | 81.75 |
| 11 | Miami (Florida) | 3 | 101 | 316 | 3.13 | 5 | 33.67 | 105.33 |
| 12 | Georgia Tech | 4 | 134 | 668 | 4.99 | 4 | 33.50 | 167.00 |
| 13 | Virginia | 4 | 113 | 655 | 5.80 | 10 | 28.25 | 163.75 |
| 14 | North Carolina State | 4 | 111 | 452 | 4.07 | 3 | 27.75 | 113.00 |