2021 Atlantic Coast Conference Leaders Rushing Offense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Duke | 4 | 187 | 993 | 5.31 | 17 | 46.75 | 248.25 |
| 2 | Syracuse | 4 | 169 | 864 | 5.11 | 13 | 42.25 | 216.00 |
| 3 | Boston College | 4 | 167 | 882 | 5.28 | 12 | 41.75 | 220.50 |
| 4 | Florida State | 4 | 163 | 973 | 5.97 | 11 | 40.75 | 243.25 |
| 5 | Virginia Tech | 5 | 199 | 685 | 3.44 | 9 | 39.80 | 137.00 |
| 6 | Georgia Tech | 4 | 157 | 655 | 4.17 | 3 | 39.25 | 163.75 |
| 7 | Pittsburgh | 5 | 191 | 750 | 3.93 | 13 | 38.20 | 150.00 |
| 8 | Louisville | 5 | 186 | 880 | 4.73 | 11 | 37.20 | 176.00 |
| 9 | Clemson | 5 | 185 | 766 | 4.14 | 12 | 37.00 | 153.20 |
| 10 | North Carolina | 4 | 147 | 858 | 5.84 | 11 | 36.75 | 214.50 |
| 11 | Miami (Florida) | 4 | 143 | 636 | 4.45 | 7 | 35.75 | 159.00 |
| 12 | Wake Forest | 4 | 132 | 653 | 4.95 | 11 | 33.00 | 163.25 |
| 13 | North Carolina State | 4 | 127 | 712 | 5.61 | 9 | 31.75 | 178.00 |
| 14 | Virginia | 4 | 120 | 637 | 5.31 | 7 | 30.00 | 159.25 |