2021 Atlantic Coast Conference Leaders Passes Defended - Games in August/September Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Wake Forest | 4 | 7 | 14 | 21 | 5.25 |
| 2 | Boston College | 4 | 6 | 12 | 18 | 4.50 |
| 3 | Duke | 4 | 5 | 16 | 21 | 5.25 |
| 3 | North Carolina State | 4 | 5 | 15 | 20 | 5.00 |
| 3 | Virginia Tech | 4 | 5 | 12 | 17 | 4.25 |
| 6 | Louisville | 4 | 4 | 9 | 13 | 3.25 |
| 7 | Miami (Florida) | 5 | 3 | 14 | 17 | 3.40 |
| 7 | Clemson | 4 | 3 | 12 | 15 | 3.75 |
| 7 | North Carolina | 4 | 3 | 8 | 11 | 2.75 |
| 10 | Virginia | 5 | 2 | 18 | 20 | 4.00 |
| 10 | Florida State | 4 | 2 | 16 | 18 | 4.50 |
| 10 | Pittsburgh | 4 | 2 | 15 | 17 | 4.25 |
| 10 | Georgia Tech | 4 | 2 | 4 | 6 | 1.50 |
| 14 | Syracuse | 4 | 1 | 8 | 9 | 2.25 |