2022 Atlantic Coast Conference Leaders Passes Defended - Games in August/September Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 7 | 16 | 23 | 5.75 |
| 2 | Clemson | 4 | 5 | 21 | 26 | 6.50 |
| 2 | Miami (Florida) | 4 | 5 | 12 | 17 | 4.25 |
| 2 | Louisville | 4 | 5 | 11 | 16 | 4.00 |
| 2 | Georgia Tech | 4 | 5 | 6 | 11 | 2.75 |
| 6 | Pittsburgh | 4 | 4 | 25 | 29 | 7.25 |
| 6 | Wake Forest | 4 | 4 | 22 | 26 | 6.50 |
| 6 | Syracuse | 4 | 4 | 12 | 16 | 4.00 |
| 9 | Florida State | 4 | 3 | 14 | 17 | 4.25 |
| 9 | Boston College | 4 | 3 | 12 | 15 | 3.75 |
| 11 | Virginia | 4 | 2 | 15 | 17 | 4.25 |
| 11 | North Carolina | 4 | 2 | 10 | 12 | 3.00 |
| 13 | Duke | 4 | 1 | 24 | 25 | 6.25 |
| 13 | Virginia Tech | 4 | 1 | 12 | 13 | 3.25 |