2021 Atlantic Coast Conference Leaders Passes Defended - Games in October Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 4 | 6 | 15 | 21 | 5.25 |
| 2 | Louisville | 4 | 5 | 26 | 31 | 7.75 |
| 2 | Florida State | 4 | 5 | 13 | 18 | 4.50 |
| 4 | North Carolina State | 4 | 4 | 16 | 20 | 5.00 |
| 4 | North Carolina | 4 | 4 | 12 | 16 | 4.00 |
| 6 | Virginia | 4 | 3 | 20 | 23 | 5.75 |
| 6 | Clemson | 4 | 3 | 18 | 21 | 5.25 |
| 6 | Virginia Tech | 4 | 3 | 13 | 16 | 4.00 |
| 6 | Miami (Florida) | 3 | 3 | 8 | 11 | 3.67 |
| 10 | Duke | 4 | 2 | 19 | 21 | 5.25 |
| 10 | Syracuse | 5 | 2 | 15 | 17 | 3.40 |
| 10 | Boston College | 4 | 2 | 8 | 10 | 2.50 |
| 13 | Georgia Tech | 4 | 1 | 11 | 12 | 3.00 |
| 13 | Wake Forest | 4 | 1 | 10 | 11 | 2.75 |