2021 Atlantic Coast Conference Leaders Total Offense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 4 | 646 | 1546 | 308 | 2192 | 7.12 | 548.0 |
| 2 | Duke | 4 | 993 | 1189 | 323 | 2182 | 6.76 | 545.5 |
| 3 | Virginia | 5 | 643 | 1990 | 381 | 2633 | 6.91 | 526.6 |
| 4 | North Carolina | 4 | 802 | 1227 | 276 | 2029 | 7.35 | 507.3 |
| 5 | Miami (Florida) | 5 | 805 | 1387 | 361 | 2192 | 6.07 | 438.4 |
| 6 | North Carolina State | 4 | 693 | 1060 | 306 | 1753 | 5.73 | 438.3 |
| 7 | Wake Forest | 4 | 753 | 969 | 293 | 1722 | 5.88 | 430.5 |
| 8 | Louisville | 4 | 635 | 1058 | 298 | 1693 | 5.68 | 423.3 |
| 9 | Boston College | 4 | 882 | 802 | 259 | 1684 | 6.50 | 421.0 |
| 10 | Syracuse | 4 | 864 | 705 | 258 | 1569 | 6.08 | 392.3 |
| 11 | Florida State | 4 | 760 | 785 | 271 | 1545 | 5.70 | 386.3 |
| 12 | Georgia Tech | 4 | 785 | 748 | 271 | 1533 | 5.66 | 383.3 |
| 13 | Virginia Tech | 4 | 563 | 763 | 264 | 1326 | 5.02 | 331.5 |
| 14 | Clemson | 4 | 505 | 677 | 250 | 1182 | 4.73 | 295.5 |