2021 Atlantic Coast Conference Leaders Rushing Offense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Duke | 4 | 187 | 993 | 5.31 | 17 | 46.75 | 248.25 |
| 2 | Boston College | 4 | 167 | 882 | 5.28 | 12 | 41.75 | 220.50 |
| 3 | Syracuse | 4 | 169 | 864 | 5.11 | 13 | 42.25 | 216.00 |
| 4 | Miami (Florida) | 5 | 183 | 805 | 4.40 | 10 | 36.60 | 161.00 |
| 5 | North Carolina | 4 | 152 | 802 | 5.28 | 8 | 38.00 | 200.50 |
| 6 | Georgia Tech | 4 | 168 | 785 | 4.67 | 7 | 42.00 | 196.25 |
| 7 | Florida State | 4 | 150 | 760 | 5.07 | 6 | 37.50 | 190.00 |
| 8 | Wake Forest | 4 | 175 | 753 | 4.30 | 9 | 43.75 | 188.25 |
| 9 | North Carolina State | 4 | 147 | 693 | 4.71 | 7 | 36.75 | 173.25 |
| 10 | Pittsburgh | 4 | 159 | 646 | 4.06 | 12 | 39.75 | 161.50 |
| 11 | Virginia | 5 | 149 | 643 | 4.32 | 7 | 29.80 | 128.60 |
| 12 | Louisville | 4 | 155 | 635 | 4.10 | 9 | 38.75 | 158.75 |
| 13 | Virginia Tech | 4 | 157 | 563 | 3.59 | 7 | 39.25 | 140.75 |
| 14 | Clemson | 4 | 123 | 505 | 4.11 | 8 | 30.75 | 126.25 |