2021 Atlantic Coast Conference Leaders First Downs - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Virginia | 6 | 35 | 121 | 15 | 171 | 28.5 |
| 2 | Wake Forest | 9 | 90 | 117 | 29 | 236 | 26.2 |
| 3 | Pittsburgh | 7 | 68 | 106 | 13 | 187 | 26.7 |
| 4 | Duke | 8 | 80 | 91 | 14 | 185 | 23.1 |
| 5 | North Carolina State | 7 | 49 | 82 | 11 | 142 | 20.3 |
| 6 | Miami (Florida) | 6 | 48 | 77 | 21 | 146 | 24.3 |
| 7 | Clemson | 6 | 51 | 61 | 14 | 126 | 21.0 |
| 8 | Florida State | 6 | 65 | 54 | 17 | 136 | 22.7 |
| 8 | Boston College | 8 | 92 | 54 | 15 | 161 | 20.1 |
| 10 | Louisville | 5 | 48 | 53 | 8 | 109 | 21.8 |
| 11 | Virginia Tech | 7 | 73 | 52 | 11 | 136 | 19.4 |
| 12 | North Carolina | 5 | 60 | 48 | 11 | 119 | 23.8 |
| 13 | Georgia Tech | 5 | 49 | 45 | 11 | 105 | 21.0 |
| 14 | Syracuse | 6 | 67 | 35 | 5 | 107 | 17.8 |