2021 Atlantic Coast Conference Leaders First Downs - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Virginia | 8 | 49 | 156 | 16 | 221 | 27.6 |
| 2 | Wake Forest | 10 | 87 | 143 | 33 | 263 | 26.3 |
| 3 | Pittsburgh | 9 | 77 | 135 | 18 | 230 | 25.6 |
| 4 | Miami (Florida) | 8 | 58 | 104 | 29 | 191 | 23.9 |
| 5 | North Carolina State | 8 | 50 | 102 | 14 | 166 | 20.8 |
| 6 | Duke | 8 | 65 | 81 | 16 | 162 | 20.3 |
| 7 | North Carolina | 9 | 107 | 80 | 24 | 211 | 23.4 |
| 8 | Georgia Tech | 8 | 65 | 77 | 19 | 161 | 20.1 |
| 9 | Louisville | 8 | 78 | 76 | 14 | 168 | 21.0 |
| 9 | Florida State | 8 | 64 | 76 | 19 | 159 | 19.9 |
| 11 | Clemson | 8 | 70 | 68 | 16 | 154 | 19.3 |
| 12 | Boston College | 8 | 72 | 55 | 18 | 145 | 18.1 |
| 13 | Virginia Tech | 8 | 83 | 53 | 11 | 147 | 18.4 |
| 14 | Syracuse | 8 | 89 | 51 | 13 | 153 | 19.1 |