2021 Atlantic Coast Conference Leaders Sacks - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 5 | 19.0 | 156 | 3.80 |
| 2 | Syracuse | 4 | 18.0 | 99 | 4.50 |
| 3 | Miami (Florida) | 4 | 8.0 | 68 | 2.00 |
| 4 | Clemson | 5 | 10.0 | 66 | 2.00 |
| 5 | Florida State | 4 | 14.0 | 60 | 3.50 |
| 6 | Virginia Tech | 5 | 9.0 | 53 | 1.80 |
| 7 | Louisville | 5 | 8.0 | 51 | 1.60 |
| 8 | Duke | 4 | 5.0 | 45 | 1.25 |
| 9 | Georgia Tech | 4 | 6.0 | 42 | 1.50 |
| 10 | Wake Forest | 4 | 9.0 | 39 | 2.25 |
| 11 | Boston College | 4 | 6.0 | 31 | 1.50 |
| 12 | North Carolina | 4 | 4.0 | 25 | 1.00 |
| 12 | Virginia | 4 | 4.0 | 25 | 1.00 |
| 14 | North Carolina State | 4 | 5.0 | 22 | 1.25 |