2021 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 0 | 5 | 2 | 7 | 7.0 |
| 2 | Miami (Florida) | 1 | 11 | 8 | 0 | 19 | 19.0 |
| 3 | Duke | 1 | 5 | 15 | 0 | 20 | 20.0 |
| 4 | Florida State | 2 | 7 | 20 | 4 | 31 | 15.5 |
| 5 | Boston College | 2 | 11 | 16 | 6 | 33 | 16.5 |
| 6 | Pittsburgh | 2 | 9 | 24 | 5 | 38 | 19.0 |
| 6 | Georgia Tech | 2 | 19 | 18 | 1 | 38 | 19.0 |
| 8 | Syracuse | 2 | 21 | 15 | 4 | 40 | 20.0 |
| 8 | Louisville | 2 | 23 | 15 | 2 | 40 | 20.0 |
| 10 | North Carolina State | 2 | 16 | 20 | 5 | 41 | 20.5 |
| 10 | Virginia Tech | 2 | 18 | 21 | 2 | 41 | 20.5 |
| 12 | North Carolina | 2 | 25 | 14 | 5 | 44 | 22.0 |
| 13 | Wake Forest | 2 | 29 | 14 | 5 | 48 | 24.0 |
| 14 | Virginia | 2 | 27 | 28 | 3 | 58 | 29.0 |