2021 Atlantic Coast Conference Leaders Opponent First Downs - Games in December/January Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 4 | 9 | 1 | 14 | 14.0 |
| 2 | Louisville | 1 | 11 | 7 | 0 | 18 | 18.0 |
| 3 | Virginia Tech | 1 | 11 | 11 | 0 | 22 | 22.0 |
| 4 | North Carolina | 1 | 17 | 9 | 1 | 27 | 27.0 |
| 5 | Wake Forest | 2 | 14 | 20 | 5 | 39 | 19.5 |
| 6 | Pittsburgh | 2 | 14 | 30 | 5 | 49 | 24.5 |