2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 1 | 0 | 1 | 0 | 0 | 7 | 7.0 |
| 2 | Miami (Florida) | 1 | 3 | 1 | 2 | 0 | 0 | 23 | 23.0 |
| 3 | North Carolina State | 2 | 3 | 2 | 3 | 0 | 0 | 27 | 13.5 |
| 4 | Syracuse | 2 | 3 | 3 | 3 | 0 | 0 | 30 | 15.0 |
| 5 | Boston College | 2 | 4 | 1 | 4 | 0 | 0 | 31 | 15.5 |
| 5 | Duke | 1 | 4 | 1 | 4 | 0 | 0 | 31 | 31.0 |
| 7 | Florida State | 2 | 5 | 3 | 5 | 0 | 0 | 44 | 22.0 |
| 8 | Virginia Tech | 2 | 6 | 1 | 5 | 1 | 0 | 46 | 23.0 |
| 9 | Pittsburgh | 2 | 7 | 1 | 6 | 0 | 0 | 51 | 25.5 |
| 10 | North Carolina | 2 | 7 | 4 | 7 | 0 | 0 | 61 | 30.5 |
| 11 | Louisville | 2 | 9 | 1 | 9 | 0 | 0 | 66 | 33.0 |
| 11 | Wake Forest | 2 | 9 | 1 | 9 | 0 | 0 | 66 | 33.0 |
| 13 | Georgia Tech | 2 | 10 | 2 | 9 | 1 | 0 | 77 | 38.5 |
| 14 | Virginia | 2 | 13 | 1 | 13 | 0 | 0 | 94 | 47.0 |