2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Virginia Tech | 2 | 8 | 1 | 7 | 1 | 0 | 60 | 30.0 |
| 2 | North Carolina State | 2 | 9 | 1 | 9 | 0 | 0 | 66 | 33.0 |
| 3 | Pittsburgh | 3 | 9 | 2 | 7 | 1 | 0 | 69 | 23.0 |
| 4 | Clemson | 4 | 11 | 5 | 8 | 1 | 0 | 91 | 22.8 |
| 5 | Boston College | 3 | 10 | 7 | 10 | 0 | 1 | 93 | 31.0 |
| 6 | Duke | 2 | 12 | 5 | 12 | 0 | 0 | 99 | 49.5 |
| 7 | Syracuse | 4 | 16 | 6 | 13 | 1 | 0 | 129 | 32.3 |
| 8 | Florida State | 4 | 17 | 5 | 15 | 1 | 0 | 134 | 33.5 |
| 9 | Wake Forest | 3 | 17 | 5 | 16 | 1 | 0 | 135 | 45.0 |
| 10 | Miami (Florida) | 4 | 17 | 9 | 17 | 0 | 0 | 146 | 36.5 |
| 11 | North Carolina | 4 | 21 | 6 | 19 | 0 | 0 | 163 | 40.8 |
| 12 | Georgia Tech | 4 | 22 | 4 | 22 | 0 | 0 | 166 | 41.5 |
| 13 | Virginia | 4 | 23 | 6 | 23 | 0 | 0 | 179 | 44.8 |
| 14 | Louisville | 5 | 23 | 10 | 22 | 0 | 0 | 190 | 38.0 |