2021 Atlantic Coast Conference Leaders Passing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 2 | 77 | 40 | 51.9 | 508 | 6.6 | 3 | 5 | 107.23 | 38.5 | 254.0 |
| 2 | Wake Forest | 2 | 51 | 28 | 54.9 | 306 | 6.0 | 4 | 3 | 119.42 | 25.5 | 153.0 |
| 2 | Florida State | 2 | 68 | 41 | 60.3 | 495 | 7.3 | 4 | 3 | 132.02 | 34.0 | 247.5 |
| 2 | Virginia Tech | 2 | 66 | 41 | 62.1 | 504 | 7.6 | 4 | 3 | 137.17 | 33.0 | 252.0 |
| 5 | Clemson | 1 | 32 | 14 | 43.8 | 120 | 3.8 | 0 | 2 | 62.75 | 32.0 | 120.0 |
| 5 | Boston College | 2 | 53 | 31 | 58.5 | 375 | 7.1 | 3 | 2 | 129.05 | 26.5 | 187.5 |
| 7 | North Carolina | 2 | 56 | 32 | 57.1 | 320 | 5.7 | 2 | 1 | 113.35 | 28.0 | 160.0 |
| 7 | Miami (Florida) | 1 | 34 | 21 | 61.8 | 199 | 5.9 | 1 | 1 | 114.77 | 34.0 | 199.0 |
| 7 | Syracuse | 2 | 52 | 39 | 75.0 | 431 | 8.3 | 3 | 1 | 159.81 | 26.0 | 215.5 |
| 7 | Louisville | 2 | 39 | 31 | 79.5 | 443 | 11.4 | 6 | 1 | 220.55 | 19.5 | 221.5 |
| 7 | Virginia | 2 | 60 | 40 | 66.7 | 523 | 8.7 | 6 | 1 | 169.56 | 30.0 | 261.5 |
| 12 | Georgia Tech | 2 | 43 | 29 | 67.4 | 438 | 10.2 | 4 | 0 | 183.70 | 21.5 | 219.0 |
| 12 | Pittsburgh | 2 | 68 | 40 | 58.8 | 524 | 7.7 | 3 | 0 | 138.11 | 34.0 | 262.0 |
| 12 | Duke | 1 | 30 | 19 | 63.3 | 324 | 10.8 | 3 | 0 | 187.05 | 30.0 | 324.0 |