2021 Atlantic Coast Conference Leaders Opponent Penalties - Games in August/September Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 41 | 332 | 10.3 | 83.0 |
| 2 | Miami (Florida) | 5 | 37 | 329 | 7.4 | 65.8 |
| 3 | Florida State | 4 | 33 | 304 | 8.3 | 76.0 |
| 3 | Virginia | 5 | 33 | 304 | 6.6 | 60.8 |
| 5 | Pittsburgh | 4 | 32 | 327 | 8.0 | 81.8 |
| 6 | North Carolina State | 4 | 31 | 257 | 7.8 | 64.3 |
| 6 | Wake Forest | 4 | 31 | 234 | 7.8 | 58.5 |
| 8 | Georgia Tech | 4 | 30 | 247 | 7.5 | 61.8 |
| 9 | Virginia Tech | 4 | 27 | 226 | 6.8 | 56.5 |
| 9 | Louisville | 4 | 27 | 225 | 6.8 | 56.3 |
| 11 | Duke | 4 | 25 | 230 | 6.3 | 57.5 |
| 12 | North Carolina | 4 | 21 | 206 | 5.3 | 51.5 |
| 12 | Boston College | 4 | 21 | 168 | 5.3 | 42.0 |
| 14 | Syracuse | 4 | 19 | 199 | 4.8 | 49.8 |