2021 Atlantic Coast Conference Leaders Opponent Penalties - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Wake Forest | 10 | 79 | 739 | 7.9 | 73.9 |
| 2 | Clemson | 8 | 71 | 565 | 8.9 | 70.6 |
| 3 | Miami (Florida) | 8 | 63 | 599 | 7.9 | 74.9 |
| 3 | Boston College | 8 | 63 | 564 | 7.9 | 70.5 |
| 3 | Florida State | 8 | 63 | 531 | 7.9 | 66.4 |
| 3 | Pittsburgh | 9 | 63 | 545 | 7.0 | 60.6 |
| 7 | North Carolina | 9 | 62 | 583 | 6.9 | 64.8 |
| 8 | North Carolina State | 8 | 57 | 461 | 7.1 | 57.6 |
| 9 | Virginia | 8 | 55 | 489 | 6.9 | 61.1 |
| 10 | Duke | 8 | 52 | 413 | 6.5 | 51.6 |
| 11 | Virginia Tech | 8 | 51 | 454 | 6.4 | 56.8 |
| 12 | Georgia Tech | 8 | 49 | 477 | 6.1 | 59.6 |
| 13 | Louisville | 8 | 42 | 328 | 5.3 | 41.0 |
| 14 | Syracuse | 8 | 37 | 336 | 4.6 | 42.0 |