2021 Atlantic Coast Conference Leaders Rushing Defense - When Winning By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Georgia Tech | 2 | 34 | 108 | 3.18 | 1 | 54 | 4 | 3 | 1 |
| 2 | Syracuse | 3 | 41 | 49 | 1.20 | 1 | 13 | 9 | 2 | 0 |
| 2 | Miami (Florida) | 3 | 58 | 159 | 2.74 | 0 | 44 | 9 | 5 | 2 |
| 4 | Boston College | 4 | 56 | 166 | 2.96 | 1 | 20 | 11 | 4 | 1 |
| 4 | Virginia Tech | 2 | 40 | 170 | 4.25 | 1 | 40 | 11 | 5 | 1 |
| 4 | Clemson | 5 | 76 | 176 | 2.32 | 1 | 23 | 11 | 7 | 2 |
| 4 | Duke | 3 | 36 | 177 | 4.92 | 1 | 25 | 11 | 6 | 1 |
| 4 | Virginia | 4 | 65 | 180 | 2.77 | 0 | 38 | 11 | 4 | 1 |
| 9 | Florida State | 4 | 47 | 203 | 4.32 | 3 | 31 | 12 | 9 | 1 |
| 10 | North Carolina State | 5 | 76 | 210 | 2.76 | 1 | 48 | 13 | 9 | 3 |
| 11 | North Carolina | 5 | 77 | 274 | 3.56 | 4 | 36 | 18 | 4 | 1 |
| 12 | Wake Forest | 9 | 97 | 418 | 4.31 | 1 | 35 | 23 | 17 | 6 |
| 12 | Pittsburgh | 9 | 135 | 464 | 3.44 | 3 | 70 | 23 | 16 | 4 |
| 14 | Louisville | 5 | 81 | 449 | 5.54 | 5 | 75 | 24 | 19 | 5 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||