2021 Atlantic Coast Conference Leaders Rushing Defense - From Opponent's 1 To 20 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida State | 10 | 48 | 84 | 1.75 | 0 | 18 | 4 | 3 | 0 |
| 2 | Louisville | 13 | 43 | 162 | 3.77 | 0 | 21 | 7 | 7 | 1 |
| 2 | Miami (Florida) | 10 | 34 | 164 | 4.82 | 0 | 23 | 7 | 7 | 1 |
| 2 | Wake Forest | 11 | 41 | 179 | 4.37 | 0 | 25 | 7 | 7 | 1 |
| 2 | Clemson | 12 | 62 | 221 | 3.56 | 0 | 24 | 7 | 7 | 2 |
| 6 | Syracuse | 12 | 50 | 170 | 3.40 | 0 | 13 | 8 | 4 | 0 |
| 6 | Duke | 12 | 54 | 302 | 5.59 | 0 | 48 | 8 | 7 | 3 |
| 8 | North Carolina | 11 | 35 | 308 | 8.80 | 1 | 91 | 10 | 7 | 4 |
| 8 | Georgia Tech | 11 | 44 | 311 | 7.07 | 0 | 68 | 10 | 7 | 3 |
| 10 | Pittsburgh | 14 | 73 | 207 | 2.84 | 0 | 23 | 11 | 8 | 1 |
| 10 | Virginia | 11 | 46 | 287 | 6.24 | 0 | 53 | 11 | 11 | 4 |
| 10 | Virginia Tech | 13 | 56 | 338 | 6.04 | 1 | 80 | 11 | 8 | 2 |
| 13 | North Carolina State | 12 | 67 | 265 | 3.96 | 0 | 34 | 12 | 9 | 4 |
| 13 | Boston College | 10 | 51 | 305 | 5.98 | 0 | 32 | 12 | 13 | 4 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||