2021 Atlantic Coast Conference Leaders Rushing Defense - On 1st Down through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 12 | 205 | 708 | 3.45 | 5 | 51 | 23 | 25 | 3 |
| 2 | Florida State | 12 | 226 | 929 | 4.11 | 6 | 63 | 29 | 30 | 4 |
| 3 | Pittsburgh | 14 | 230 | 678 | 2.95 | 5 | 70 | 21 | 21 | 6 |
| 3 | Virginia Tech | 13 | 234 | 993 | 4.24 | 8 | 61 | 27 | 28 | 6 |
| 3 | Georgia Tech | 12 | 231 | 1025 | 4.44 | 7 | 68 | 26 | 27 | 6 |
| 6 | Clemson | 13 | 212 | 782 | 3.69 | 4 | 54 | 18 | 17 | 8 |
| 6 | Syracuse | 12 | 207 | 876 | 4.23 | 4 | 65 | 23 | 24 | 8 |
| 8 | Virginia | 12 | 221 | 1194 | 5.40 | 8 | 63 | 31 | 31 | 10 |
| 9 | North Carolina State | 12 | 201 | 794 | 3.95 | 6 | 55 | 24 | 25 | 11 |
| 10 | Louisville | 13 | 232 | 1155 | 4.98 | 8 | 41 | 41 | 41 | 12 |
| 10 | Boston College | 12 | 225 | 1181 | 5.25 | 4 | 51 | 33 | 38 | 12 |
| 12 | Duke | 12 | 231 | 1241 | 5.37 | 8 | 72 | 35 | 37 | 13 |
| 12 | Wake Forest | 14 | 269 | 1487 | 5.53 | 9 | 50 | 54 | 57 | 13 |
| 14 | North Carolina | 13 | 243 | 1271 | 5.23 | 11 | 91 | 41 | 39 | 15 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||