2021 Atlantic Coast Conference Leaders Rushing Defense - When Losing By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 1 | 5 | 3 | 0.60 | 0 | 3 | 0 | 0 | 0 |
| 1 | Florida State | 2 | 27 | 67 | 2.48 | 0 | 10 | 3 | 2 | 0 |
| 1 | Wake Forest | 2 | 24 | 78 | 3.25 | 1 | 16 | 5 | 2 | 0 |
| 1 | Syracuse | 3 | 40 | 104 | 2.60 | 0 | 19 | 6 | 4 | 0 |
| 5 | Miami (Florida) | 2 | 33 | 122 | 3.70 | 1 | 20 | 7 | 5 | 1 |
| 5 | North Carolina | 4 | 28 | 156 | 5.57 | 1 | 50 | 7 | 4 | 1 |
| 5 | Virginia | 3 | 35 | 165 | 4.71 | 0 | 31 | 7 | 4 | 1 |
| 5 | Boston College | 4 | 70 | 274 | 3.91 | 1 | 41 | 16 | 9 | 1 |
| 9 | Virginia Tech | 4 | 58 | 267 | 4.60 | 3 | 22 | 13 | 9 | 2 |
| 10 | Louisville | 3 | 50 | 341 | 6.82 | 6 | 41 | 18 | 16 | 5 |
| 10 | Georgia Tech | 4 | 75 | 517 | 6.89 | 4 | 68 | 22 | 12 | 5 |
| 12 | Duke | 7 | 162 | 941 | 5.81 | 12 | 72 | 49 | 27 | 8 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||