2021 Big 12 Conference Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma | 11 | 2033 | 2764 | 700 | 4797 | 6.85 | 436.1 |
| 2 | Iowa State | 11 | 1769 | 2922 | 730 | 4691 | 6.43 | 426.5 |
| 3 | TCU | 10 | 2007 | 2346 | 663 | 4353 | 6.57 | 435.3 |
| 4 | West Virginia | 12 | 1409 | 2879 | 812 | 4288 | 5.28 | 357.3 |
| 5 | Baylor | 11 | 2110 | 2163 | 725 | 4273 | 5.89 | 388.5 |
| 6 | Oklahoma State | 10 | 1919 | 2305 | 766 | 4224 | 5.51 | 422.4 |
| 7 | Texas Tech | 10 | 1556 | 2539 | 650 | 4095 | 6.30 | 409.5 |
| 8 | Texas | 10 | 1794 | 2247 | 673 | 4041 | 6.00 | 404.1 |
| 9 | Kansas State | 11 | 1634 | 2293 | 616 | 3927 | 6.38 | 357.0 |
| 10 | Kansas | 10 | 1418 | 1817 | 619 | 3235 | 5.23 | 323.5 |