2021 Big 12 Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Texas | 5 | 676 | 1230 | 320 | 1906 | 5.96 | 381.2 |
| 2 | Iowa State | 5 | 487 | 1336 | 356 | 1823 | 5.12 | 364.6 |
| 3 | Baylor | 5 | 1048 | 741 | 319 | 1789 | 5.61 | 357.8 |
| 4 | Oklahoma State | 4 | 659 | 1030 | 330 | 1689 | 5.12 | 422.3 |
| 5 | TCU | 3 | 410 | 1016 | 197 | 1426 | 7.24 | 475.3 |
| 6 | Oklahoma | 3 | 593 | 672 | 206 | 1265 | 6.14 | 421.7 |
| 7 | Texas Tech | 4 | 398 | 852 | 229 | 1250 | 5.46 | 312.5 |
| 8 | Kansas State | 3 | 267 | 676 | 175 | 943 | 5.39 | 314.3 |
| 9 | West Virginia | 3 | 174 | 567 | 195 | 741 | 3.80 | 247.0 |
| 10 | Kansas | 3 | 374 | 347 | 167 | 721 | 4.32 | 240.3 |