2021 Big 12 Conference Leaders Passes Defended - Games in December/January Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 2 | 7 | 11 | 18 | 9.00 |
| 2 | Kansas State | 1 | 2 | 2 | 4 | 4.00 |
| 3 | Oklahoma State | 2 | 1 | 11 | 12 | 6.00 |
| 3 | Texas Tech | 1 | 1 | 7 | 8 | 8.00 |
| 3 | Iowa State | 1 | 1 | 4 | 5 | 5.00 |
| 3 | Oklahoma | 1 | 1 | 1 | 2 | 2.00 |
| 3 | West Virginia | 1 | 1 | 1 | 2 | 2.00 |