2021 Big 12 Conference Leaders Passes Defended - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Kansas State | 6 | 7 | 18 | 25 | 4.17 |
| 2 | Oklahoma State | 4 | 6 | 5 | 11 | 2.75 |
| 3 | Baylor | 5 | 5 | 21 | 26 | 5.20 |
| 3 | Iowa State | 5 | 5 | 15 | 20 | 4.00 |
| 3 | West Virginia | 4 | 5 | 5 | 10 | 2.50 |
| 3 | Kansas | 4 | 5 | 4 | 9 | 2.25 |
| 7 | Texas Tech | 5 | 3 | 15 | 18 | 3.60 |
| 8 | TCU | 4 | 2 | 9 | 11 | 2.75 |
| 8 | Oklahoma | 6 | 2 | 7 | 9 | 1.50 |
| 10 | Texas | 4 | 0 | 13 | 13 | 3.25 |