2021 Big 12 Conference Leaders First Downs - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 98 | 102 | 26 | 226 | 22.6 |
| 1 | Oklahoma | 10 | 86 | 126 | 14 | 226 | 22.6 |
| 3 | West Virginia | 10 | 88 | 122 | 15 | 225 | 22.5 |
| 4 | Baylor | 9 | 108 | 93 | 6 | 207 | 23.0 |
| 5 | TCU | 9 | 93 | 82 | 16 | 191 | 21.2 |
| 5 | Texas Tech | 9 | 86 | 97 | 8 | 191 | 21.2 |
| 7 | Kansas State | 10 | 94 | 83 | 10 | 187 | 18.7 |
| 8 | Iowa State | 8 | 66 | 100 | 9 | 175 | 21.9 |
| 9 | Texas | 7 | 86 | 62 | 9 | 157 | 22.4 |
| 9 | Kansas | 9 | 69 | 80 | 8 | 157 | 17.4 |