2021 Big 12 Conference Leaders First Downs - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 104 | 113 | 30 | 247 | 24.7 |
| 2 | Iowa State | 9 | 66 | 118 | 17 | 201 | 22.3 |
| 3 | Baylor | 10 | 98 | 91 | 11 | 200 | 20.0 |
| 4 | West Virginia | 9 | 76 | 105 | 17 | 198 | 22.0 |
| 5 | Oklahoma | 9 | 69 | 105 | 14 | 188 | 20.9 |
| 6 | Texas | 9 | 88 | 87 | 9 | 184 | 20.4 |
| 7 | TCU | 9 | 84 | 81 | 10 | 175 | 19.4 |
| 8 | Texas Tech | 9 | 69 | 91 | 13 | 173 | 19.2 |
| 9 | Kansas State | 9 | 64 | 78 | 10 | 152 | 16.9 |
| 10 | Kansas | 9 | 64 | 74 | 8 | 146 | 16.2 |