2021 Big 12 Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Baylor | 5 | 23.0 | 166 | 4.60 |
| 2 | Oklahoma State | 4 | 17.0 | 121 | 4.25 |
| 3 | Iowa State | 5 | 14.0 | 81 | 2.80 |
| 4 | Texas | 5 | 8.0 | 53 | 1.60 |
| 5 | Texas Tech | 4 | 6.0 | 40 | 1.50 |
| 6 | Kansas State | 3 | 6.0 | 35 | 2.00 |
| 7 | Oklahoma | 3 | 5.0 | 25 | 1.67 |
| 7 | Kansas | 3 | 4.0 | 25 | 1.33 |
| 9 | TCU | 3 | 3.0 | 24 | 1.00 |
| 10 | West Virginia | 3 | 5.0 | 23 | 1.67 |