2021 Big 12 Conference Leaders Sacks - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Baylor | 4 | 18.0 | 138 | 4.50 |
| 2 | Oklahoma State | 4 | 13.0 | 93 | 3.25 |
| 3 | Oklahoma | 4 | 16.0 | 91 | 4.00 |
| 4 | Texas Tech | 4 | 12.0 | 89 | 3.00 |
| 5 | West Virginia | 4 | 11.0 | 85 | 2.75 |
| 6 | Kansas State | 4 | 12.0 | 76 | 3.00 |
| 7 | Iowa State | 4 | 10.0 | 64 | 2.50 |
| 8 | Texas | 3 | 7.0 | 37 | 2.33 |
| 9 | TCU | 3 | 3.0 | 19 | 1.00 |
| 10 | Kansas | 3 | 2.0 | 8 | 0.67 |