2021 Big 12 Conference Leaders Opponent Penalties - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Kansas State | 1 | 8 | 62 | 8.0 | 62.0 |
| 2 | Oklahoma | 1 | 6 | 48 | 6.0 | 48.0 |
| 2 | Iowa State | 1 | 6 | 47 | 6.0 | 47.0 |
| 4 | Texas Tech | 2 | 11 | 95 | 5.5 | 47.5 |
| 4 | Texas | 2 | 11 | 65 | 5.5 | 32.5 |
| 6 | Oklahoma State | 3 | 13 | 126 | 4.3 | 42.0 |
| 7 | Kansas | 1 | 4 | 40 | 4.0 | 40.0 |
| 7 | TCU | 1 | 4 | 30 | 4.0 | 30.0 |
| 9 | Baylor | 2 | 5 | 40 | 2.5 | 20.0 |