2021 Big 12 Conference Leaders Opponent Penalties - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 33 | 226 | 8.3 | 56.5 |
| 2 | Kansas State | 3 | 21 | 189 | 7.0 | 63.0 |
| 3 | Iowa State | 5 | 30 | 324 | 6.0 | 64.8 |
| 3 | Baylor | 5 | 30 | 250 | 6.0 | 50.0 |
| 3 | Oklahoma | 3 | 18 | 150 | 6.0 | 50.0 |
| 6 | Texas Tech | 4 | 23 | 222 | 5.8 | 55.5 |
| 7 | West Virginia | 3 | 17 | 149 | 5.7 | 49.7 |
| 8 | Kansas | 3 | 16 | 125 | 5.3 | 41.7 |
| 9 | Texas | 5 | 19 | 155 | 3.8 | 31.0 |
| 10 | TCU | 3 | 10 | 95 | 3.3 | 31.7 |